I like how startups ran out of regular words, so now they use V instead of U and we have a whole new set of words to go through.
It was a half-joke, but the name stuck and now I wish I picked something else. The problem, obviously, that it's unpronounceable. As "online" as the life is right now, people still communicate in person and the name like this is a stumbling block. Though on the other hand this is what makes it memorable. So, all in all, V-mangled names may not be a bad idea, but only for as long as yours is the only one in its respective domain.
I'm not sold yet on using something other than .com for a consumer-facing startup, unless it's not web-focused (maybe mobile apps can get away with non .com tlds).