1) The windows are disappointing. This is, I think, due to the fatigue caused by large rectangular windows that previously caused a disaster but it begs for improvement. A way to make large windows or get rid of all the windows and use very high definition screens to imitate windows with live footage would be nicer
2) Noise is still a problem. I am sure they are trying hard, even the engines are designed around addressing the noise issue but it would be a huge improvement to have this solved. ANC maybe?
3) Automate the pilot out. This is I believe an area where plane makers are pioneers but we still got pilots, I would love to see flying with a plane becoming about the same as taking an elevator.
IMHO travel times are reasonable, the improvements in comfort, cost and practicality are due. Airports themselves too are due for an overhaul, it shouldn't be taking hours to get on a travel machine.