Gaming, it is mostly Windows games via Proton, hardly any different from using MAME, FS-UAE, Amiberry,...
Graphics, most of the well known commercial packages for VFX, 3D modeling, visualisation, lack a Linux version.
Laptops, just two years ago I failed to make UEFI work with the myriad of distributions I tried out, unless booting from external USB drive, and even then there was the whole termal configuration.