Even NASA considers rotational gravity to have huge obstacles rendering it impractical. https://technology.nasa.gov/patent/TOP2-311
I suppose this also involves mass-balancing the inhabitants!
What does the Coriolis effect mean in this context?
As far as I can tell, there's no reason to believe that Coriolis will be harmful to humans beyond nausea and disorientation. If you ran quickly through the station it might cause you to fall. Possibly it might make machinery that deals with fluids more difficult to deal with. I would chalk it up as a relatively minor concern compared to other issues.