One of the interesting things in that Wikipedia link is that you only need to run your Orion for 36 days to get it up to speed. Beyond that, detonating more bombs won't accelerate you any further.
So yes, you could turn it around. But surprisingly it seems you can wait until a month before arrival to do so. The downside, however, is that your max velocity gets cut in half if you bring enough bombs to slow down.
With better explosives, you could get a higher max velocity and therefore closer to the "accelerate halfway, decelerate halfway" ideal case, but at the moment such explosives don't exist.