There's a lot of indirect evidence for this from the fact that some naive attempts at stopping aging give you cancer, like turning telomerase on indiscriminately.

Almost everything in nature has multiple functions or causes, but one cause of aging is probably an evolutionary compromise between longevity and not getting cancer.

One option, I guess, would be turning the guard rails off and just getting incredibly good at treating cancer or inventing some extraneous cancer detection and killing mechanism.