The handwritten SIMD kernels sit behind safe Rust wrappers that calculate or validate the exact slice bounds before producing raw pointers, and CPU-specific routines are only installed after runtime feature detection. wpd even has guard-page tests specifically checking that the assembly kernels don't read or write beyond those wrapper-established windows. Handwritten SIMD was valuable enough that we felt this was all worth it (see some of the dav1d talks for justifications, we share these views).
Wuffs does still have a stronger formal property in the fact that its compiler checks the loads & stores inside the SIMD implementation itself, but most of the interesting memory safety attack surface (parsing and decoding attacker-controlled structure) remains entirely in safe Rust in wpd anyway, so I think wpd is still safe and incontrovertibly a significant improvement over libwebp anyway.
P.S. you can disable wpd's assembly if you feel so inclined, and get similar performance to Wuffs with safety.