Any theory about any phenomenon in the world has "things" to do with these. These are universal physical and mathematical laws. If your theory violates this, you have to disprove physics first or admit your theory is wrong.
ANd yes, an example would be Penrose believes something in the brain is non-computable. However Penrose is a very excellent thinker as far as the standards for consciousness theories go, for he posited a physically testable theory as far as I know. Even if it turns out to be wrong, this is worthy of respect.