If you look at the TODO list, it looks like they want to replicate PyPy's approach. I wonder, have they considered writing an rjavascript to rpython compiler and just using the pypy infrastructure as is?
Perhaps pairing PyPy with emscripten would be the ideal solution for this, but that would have to be a completely new project because nothing that's currently in Continuum would be useful for that (except probably the standard library that's written in ES6 and executed in the VM).
Still, I would recommend trying to reuse PyPy's infrastructure, even if only for the short term. An immense amount of time and thought has gone into creating it that you would end up replicating otherwise.
Besides, PyPy doesn't just target C, it also target's JVM and .Net, so in writing a new backend for JS, you wouldn't be working against the grain.