Oh wow I hadn't heard of CSS Painting API. At first glance it seems like a "frame buffer" you can write to directly, kind of like the web audio worklet processor but for styling.
I've always wished more of the underlying CSS functionality were exposed to the scripting side, like calculating flex/grid layouts, without necessarily tying it to performance-critical painting path. Usually more expressive power means more responsibility, but there are already web APIs that do it in a controlled way, like request animation frame. So I can appreciate the potential of the Painting API and others in a similar direction.
At the same time, I also wish there was effort in the complete opposite way, to start over "from scratch" and make it easier (or possible at all) for people to build alternative browsers with a minimal subset of CSS. Perhaps something like a modularization of web technology, where the current hugely complex system is broken down into reusable libraries for building small and large browser-like applications. I know something like that exists, like Servo etc., but much smaller and simpler building blocks.