Malware is a solved problem already since Vista shipped even on windows. I haven't seen one in ages on the maybe 20-30 friend pcs that I am the involuntary "IT" guy.
People like iDevices. Period. But one of the engines of innovation is being able to use something for purpose other than the one envisioned by its creator. It creates positive feedback loop. Which include running software that somebody might not approve. Also unlocked does not mean defenseless. Sandboxing and isolation are good things, so is the vetting of the apps in the store.
I think that the HTC model currently is best - device comes locked, with official unlock available that voids part of the warranty. If I want security - I got it. But if i want to use 300 of them mounted on the ceilings of the clubs uploading realtime feeds to show the hottest places in town right now - I can use them for that too.