The issue is mainly with HN users not bothering to read the submissions and just writing armchair commentary on either side of the debate.

The authors of this study have identified the upstream protein responsibile for the anti-ageing effects in mice, that this protein has anti-senescent effects on human cells, that this protein drops with age in humans, that it drops more in humans with age-related disease and that this protein could have a protective effect in multiple chronic diseases in humans based on mendelian randomization.

This implies a stronger therapeutic potential than just a "nothingburger study".