Absolutely. And discs as well. I had an x-ray recently and asked them to give me the image so I could take it to a different clinic, and they burned it onto a CD. So I suppose optical media is sort of irreplaceable for medical applications at least.
Starting with, iirc, XP, Windows started prompting you whether you'd like to run the autorun.
One would think that some sort of common EDI would have come around by now.