making bread yeast for example, or playing with bioluminescent bacteria?

You can actually do real biology at home if you set up a Petri dish tray with a concentration gradient of Clorox across it, then put some random germs at the low concentration and.

The 0.01% might survive, even develop some resistence. But when put again in the mix with wild non-resistent individuals in a non-clorox environment, the selection acts against them: having resistence might have costs, have no use, and if the mechanism is lost for whatever reason the new individuals survive anyway.

Something like this is suspected to have happened to us humans: the black plague has been pressuring/selecting individuals with more active and strong immune systems. Today the plague isn't so active or deadly to humans, but stronger immune systems are probably behind auto-immune illnesses (https://aihep.org/post/the-bubonic-plague-and-autoimmune-dis...).