A friend I've known since high school gave up a very lucrative career as a managing consultant to become... a farmer. Yup, he plants stuff and sells them at a bi-weekly market and keeps going in the winter thanks to his greenhouse. Currently engaged to a lovely lady and, to my surprise and delight, he's completely happy.
It's a funny thing to feel like the industry you're good at (or been cornered into) is really not how you want to spend your life. And may in fact be zapping what life and vigor you have.
Which is why, I've been improving my carpentry while keeping up with automation tech (Arduino, Raspberry pi, Beaglebone etc...) so when I build my smart green house and cabin, I can get down to what I really want to do.
Making soap.
Side note: This isn't as crazy an idea as you might think. http://www.youtube.com/watch?v=3IryIOyPfTE