Clojure is currently my favorite language, partly for the pragmatic choices it made, but these pragmatic choices will limit its continued use.

Hygienic macros often prevent one from shooting oneself into the foot, but they prevent also some truly elegant code. Having lists and vectors with a common interface is cool, but that the semantics of conj is different for both is annoying. Easy java interop is worth a lot, but it prevents call/cc.

It's probable that i will gladly use Clojure for the next 10, maybe even 20 years, but it won't be the programming language my grandchildren will ask me to shut up about.