The film breaks out of the mold of 3D animated film art direction with stylized characters and it prefers graphic shapes over the hyper-realism so common in the genreThey did this with WALL-E first, with the juxtaposition between the two main characters.
WALL-E was a square, while Eve was essentially a circle (Andrew Stanton's words, not mine).
Same thing is happening in UP, Carl Fredrickson (the old guy) represents the square, while Russel (boy scout) represents the circle and it is really more prevalent, even with Carl's finger's having a rough rectangular shape.
Pixar used to be lauded for its originality and commitment to high quality.
A little anecdote on just how committed they are.
During the production of Finding Nemo, a couple of Pixar artists climbed inside the mouth of a dead beached whale in California just to get a good idea of the textures inside of it for the scene between Dory and Marlin when they were inside the mouth of a whale.
That's commitment to quality.