In theory this is priced in already. Lost BTC is treated no differently than "hoarded" BTC; in either case it doesn't contribute to market liquidity.
Bitcoins shouldn't be considered an investment -- the business about hoarding them like taxi medallions because they only go up in value is nonsense. Their value is limited by the low transaction fee for another blockchain. But you're right, you'd have to factor that in if you were actually investing.