There are ~30k genes (encoded protein sequences).
100,000 human individuals may or may not have that many deltas per gene.
The data is naturally structured. There is no reason to believe that looking at 72TB at once is useful. You would start by looking for correlations with particular genes. (Even correlations with random genes is merely 30,000 simple problems.)
This kind of work can be done on a single multicore computer with a lot diskspace and memory, if you have the right tools.
But yes, the day will come when it's feasible to simply sequence and compare large numbers of genomes. But by the time sequencing technology has got that much better, so will computers have!