Running #! myself right now, having tried various other distros over the years. It's my main desktop environment for when I'm not gaming, being very fast and sane.

The main advantage it has over Debian, Mint, or (shudder) Ubuntu is that it is a no-bullshit setup of Debian with all of the normal tweaks I'd eventually add myself. It already starts with a solid setup of Openbox, and competently brings up the non-free software I'd be using anyways right at install time via a friendly little script.

And, unlike Ubuntu or Mint, it seems to be a fairly small shim over stock Debian--which makes getting things to work a hell of a lot easier.

Also, for anybody running it (or other .deb compatible distros), check this out:

http://www.compholio.com/netflix-desktop/

It's a nicely trimmed-up version of Wine with Silverlight that generally does the right thing and lets you watch Netflix from your Linux.