D. Richard Hipp, the inventor and primary developer of SQLite considers the rock-solid reliability of SQLite of primary importance, which is one of the reasons everything from iOS to Skype uses it. (The fact that it has a public domain license doesn't hurt.) He lists the potential pitfalls of using this method on the page: http://www.sqlite.org/mmap.html and leaves it to users to determine if those risks are acceptable to them. I'm sure he's been thinking about this method for a while.