Isn't this what asm.js attempts to provide? With mature tooling it should be possible to code in whichever language and compile or run on top of a VM which itself runs atop asm.js without having to worry about the underlying JS much at all (unless you want serious optimisation).

It wouldn't surprise me if we eventually come full circle and discard the DOM entirely. Each web application is just a giant <canvas> with QT or something compiled to JS providing the UI elements.