The real answer is I have. I'm a PyPI administrator now and have been enacting a lot of these benefits on PyPI itself. Just this weekend I've deployed a CDN in front of all of PyPI so that package downloads have sped up by 1-3 orders of magnitude depending on location.
Previously I had pushed hard for getting a real valid and trusted SSL certificate on PyPI, moving the user provided html/js from packages.python.org to pythonhosted.org in order to prevent CSRF fixation attacks.
Like I said Crate is an experiment. One that has enabled me to push for good changes in PyPI.