It is a rephrasing of "There ain't no such thing as a free lunch". It is safe to assume that
everything has side effects and the side effects are going to be roughly proportionate to the primary effects. If you think there are no side effects, then you have not looked hard enough.
This is a fairly cynical point of view. But safe. We are not talking about medicine, we are talking about messing with otherwise perfectly healthy people.
Off the top of my head, vitamins and vaccines are the only side-effect free wonder drugs for healthy people. Similarly, clothing is the only body augment to fit this category. (And even then we get it wrong sometimes. Lots of examples from women's fashion in the past and currently the debate about shoes's effects on the knees/back.)