I bike commute in Boston (Live in Somerville, bike into Boston), and while there's definitely a risk, I feel pretty safe doing so - there are a lot of good bike lanes that make it possible. I definitely agree with your recommendations - need to be very aware of the cars around you (assume everyone in a car is an idiot/out to get you), and I wear a neon jacket, along with lights when it's dark. I definitely feel like it's only a matter of time until I get doored, though. . .