That depends on the target. I selected them because they represent different aspects of the state of the art.
> ... and I would argue that modern JS VMs are competitive with them in many respects
But not all, and in many places, not even close. JS VMs make trade-offs that we don't need if we abandon JS, and on top of it all, you have Mozilla insisting against shared-state multi-threading supported and exposed by the VM, which discards enormously important optimization opportunities) -- and that's just the tip of the iceberg.
Get rid of JS, get rid of Mozilla's self-enforced constraints on the browser, and look very seriously at something like NaCL which blends native execution performance (including being able to drop to SIMD instructions) with security sandboxing.
Let language authors target the low-level machine, and target your high-level general purpose bytecode.
Once you've built a runtime in which I could implement a JS runtime that's as performant as yours, we will no longer be operating in a two-tier universe in which browser makers think that JS is good enough for everyone but themselves.