Which is to say, if you remove all your goal conditions, all your reference points that could be moved away from center to provoke response -- if you are reduced to http://wiki.lesswrong.com/wiki/Orgasmium, in other words -- are you really aware any more?
It's me; and I'd be happy to give up the biological machine I'm running on and trade it for an equivalent or better technological machine or VR environment where the limits of biology no longer applied. Removing my biology doesn't remove all of my goal conditions; it removes the ones nature imposed upon me. I could add back any I like and choose to drop those I don't.
We're intelligent beings who have transcended being driven by instinct alone; we can choose our own goals independent of nature.
Update: some links
The little brain on the heart: http://www.ccjm.org/content/74/Suppl_1/S48.full.pdf
Does changing the heart mean changing personality? A retrospective inquiry on 47 heart transplant patients: http://www.ncbi.nlm.nih.gov/pubmed/1299456
How come people who get a heart transplant don't become different people?