What's important about that is: you are not getting an accurate read of a candidate's state of mind in a high-stakes interview. I think you have just a couple of options to improve your accuracy given that fact:
* You can take deliberate steps to lower the stakes in your interview process by changing the kinds of transactions that happen in the interview (for instance, by constructing interviews that involve collaborating on a problem instead of challenging the candidate).
* You can "discount" the signals you get from the interview, particular w/r/t already nebulous concepts like "confidence", "social skill", "enthusiasm", and the dreaded "culture fit".
* You can push more of the recruiting process into situations where the candidate controls their environment (for instance, by doing stuff at home, and on a fixed but flexible time scale) and less on in-person timeboxed interviews.
I'd love more ideas. We're trying all three, but it's a lather-rinse-repeat kind of situation. I'm getting good, I think, at spotting signals that are probably the result of jitters. And I think I've learned pretty conclusively that those jitters have zero correlation to on-the-job performance. But I have so much more to learn.