Well for example the shelve management of the cartride game systems. If you would want to produce a game for the SNES, to actually distribute it you would have to put it on a cartridge and sell it.
But the design and specifications of these cartridges was protected by Nintendo, so the only way to distribute a game was to ask Nintendo for cartridges. Because Nintendo would only allow quality games on its shelves, it would test your game before allowing you any cartridges, so your game basically had to be nearly finished before you could ask Nintendo for cartridges. Of course if you were refused at this point you would have already invested tons of money so it would be pretty ruinous.
Besides the go/no-go signal, Nintendo also controlled the _amount_ of cartridges you would get. If Nintendo decided (much like Apple did in recent years) that your game was more valuable if it had limited copies, then you wouldn't get many copies, regardless if that would leave you with not enough revenue to make a profit.
Reasons for refusal of cartridges were both fair and rather unfair. For example you could be refused for lack of quality, but you could also be refused because another game in your genre already had shelve space and they didn't want to endanger its dominance. Basically you were at the complete mercy of how Nintendo wanted to make maximum profit for it self.
I have heard, though I don't know for sure (maybe someone could check it :P) that Atari eventually went bankrupt because it decided to make a Nintendo game (as a last resort perhaps), got into a conflict with Nintendo, sued them, and lost..