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I'm a big fan of knockout. Learned it about a year ago and it has saved me from writing a lot of code. I can't see going back to the old way at this point. It doesn't try to be everything, but what it does, it does well. For SPA I use Durandal, knockout runs the declarative binding so you can get up and going with a full blown SPA pretty quickly.

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Durandal and Knockout make a great combination for SPA applications. My only gripe about Knockout is that some of the useful built-in utilities (ko.utils) are not officially documented anywhere and of course the observable syntax can get unwieldy at times (parentheses) and difficult to maintain (this can be remedied by durandal.observable plugin if we target newer browsers, though).

Absolutely agree with all of that. Parentheses was my biggest hurdle in learning Knockout. Refactoring is a bit of a challenge also if you go from unobservable -> observable because of all of the parentheses.

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