I would like to play it in the browser.
Things I'd like to see:
Nice graphics. Doesn't have to be high res or anything, just nice. Perhaps allow tilesets to be used so the community could easily create and share tiles.
Easy laying of road and track. I remember the odd rubber banding of classic being a bit frustrating.
Some nice easy to use terrain editor.
Some social features? Allow more than one person to work on a terrain map at a time? (I understand this raises complexity significantly). Or Allow people to passively view the terrain and sent chat suggestions?
Have a free play version, and a well tested challenges version with a wide variety of challenges. Eg "last X years", "grow to Y size", "survive these disasters", "earn Z money" etc.
Have a way for me to pay you. I much prefer a single payment for full access rather than a freemium model. (Wait x hours to collect enough coins to build this road, or unlock coins for $x now!!" Would not be pleasant.
Hope these are some use!