It's interesting to me that both duodecimal and decimal counting are recommended as being easy to calculate with.
The benefits of decimal come from our using base-10 for other purposes. I guess the best of all possible worlds would be to use duodecimal for all units (including our normal number system).
Then we'd get the ease of use of modern base-10 units plus the better factorisation of duodecimal.
(But we'd still have an impedance mismatch with the binary powers. The KB/KiB split wouldn't go away).