Hmm... addiction makes it so you can't really trust people's decisions surrounding their own health and having lots of addicts looking to get their next fix at any cost means lots of petty crimes.
Disease and crime are hugely damaging to society. You might (in internet-"libertarian" fashion) decide that people should be free to damage themselves, and that health insurance providers should be free not to cover those people (and you'd have a completely logical rationale for being a selfish asshole), but how do you account for the additional costs to the security infrastructure from the crime?
With socialized security infrastructure (state run police and prisons) everyone pays for the damage that drug manufacturers and importers are doing to society. Without it (private security/insurance) you could decide that premiums for those services will just follow the increase in drug-related crimes in a given locality, but then you've completely given up on solving the root causes, and we'd just have the same kind of security profiteering surrounding drug use we see now, minus a whole lot of effectiveness.
Do all of the people who resist addiction and want to have a decent level of security in their lives and possessions move to gated communities? What about the ones who are not so privileged? Do we just give up on entire neighborhoods of addicts and those too poor to leave.
Certainly, prosecuting users and low-level dealers with hugely inflated mandatory minimums is a crime against them and their families. Certainly, criminalizing production of tobacco, alcohol, or cannabis inhibits the potential for economy surrounding them without much benefit to society.
Is the value of preventing the import and production of hard and/or impure drugs like methamphetamine and the damage that their use does to civilization not as certain?
It seems pretty obvious to me that having social infrastructure surrounding drug laws and their enforcement, and treatment for addicts is hugely beneficial - society benefits as a whole so everyone should pay, and there is definitely potential for benefit greater than the costs (I suspect that even as bad as we are screwing this up now, we are past the break-even). It seems pretty obvious to me that we must disconnect sentencing from politics by making mandatory minimums unconstitutional - judges and juries must be free to sentence as they see fit. And it seems pretty obvious to me that we must refocus law enforcement on the sources of drugs, not the users or dealers - who are mostly victims of social effects and mental behaviors which are outside their control (this is very likely to mean reduced spending in total surrounding drug law enforcement).