No, because it would help spammers identify valid addresses.
Think about it this way: if there was an auto-unsubscribe mechanism, which ethical bulk email senders honored and spammers didn't, then it would become much easier to filter spam: any message that clusters into a message-cluster that the system has sent out an unsubscribe-request for already, is junk.
Every spammer who wanted to "trick" the auto-unsub mechanism would basically have to first dox themselves for all the world to see. And any certificate that turned out to not be a valid means of contacting the spammer would be quickly revoked.
Because then they can dictionary attack a large list of random emails, send out a trivial campaign, and collect a list of valid users then sell it to someone else.