I disagree. Portugal enabled a legislation similar to Mexico a couple of years ago and the drug consumption didn't get higher (I read about it in Newsweek about 3 months ago). Like Mexico, Portugal is also a route for drugs.
Also, untill the first decades of 20th century drugs like cocaine and marijuana were legal in most countries in the world. And their consumption wasn't actually that high. In the US the biggest consumers of cocaine were the workers on docks (to endure the hard work), farmers' wives (to endure boredom) and doctors (because it was so easily available for them).