I don't think anyone knows what the world will look like in a million years. Will we be around as a species? Given the tendency toward exponential progress in all things we do, I tend to think that within 10,000 years, we'll either be off the planet or extinct. (That's not to say that we're destined to make the Earth uninhabitable, although that could happen. I just think we're "up or out" as a species. We'll either end economic scarcity or kill ourselves off within 500 years, I'd say, and the former means we're mining asteroids and, over the millennia, moving to other planets.)

If we get off the planet, it's unclear what we'll "look like" in many ways. We could be cyborgs. We could have enormous lifespans (millions of years). Unless we achieve such an immortality, we will continue to evolve (physically and culturally) and after a million years on different planets, we'll probably see all sorts of variation in terms of number of digits, representation of knowledge, and language.

So, looking a million years out, the answer is probably "no". Our system may still be alive, but if we're alive in a million years, I'd bet that we're off the planet and human culture will have forked, making the question of what is "final" unclear.

For the next 500 years (even 2500) I don't think we'll see another numeral system. Arabic Base-10 works, and there isn't much ti be gained in changing it . The glyphs themselves may evolve (our "Arabic" numbers look nothing like the original Arabic digits) but the concept will be the same.