for some openings, the 'paths' do not really matter. You might have 25 transpositions leading up to the same position after 10 moves. A well known example is the classic isolated d4 pawn position that might come from:
- Nimzo Indian
- Caro-Kann Panov
- QGD
- Slav
- c3 Sicilian
- Alekhine's defence
and others.
Popularity has not a lot to do with the openings themselves but with other things like a good book being published, or a popular match (like WC).
Another thing you have is that some variations are really popular, and have good results, but are at one point refuted by a single game. As a result of this, the variation dies. but remains to have very good statistics.