http://www.techempower.com/benchmarks/#section=data-r9&hw=i7...
Looking at only python frameworks using ORM, Flask with SQLA hits 85% of the requests/sec of Django using pypy, and only 73% on stock python. Django has decently lower latency as well (450ms django, 550ms flask pypy, 600ms flask stock python):
http://www.techempower.com/benchmarks/#section=data-r9&hw=i7...
Really, if performance matters at all and you want an ORM use Java. The fastest python solution using an ORM is a tenth as fast as the Java solutions, with literally 10x the latency. :P Flask making raw db queries gets within 2x of this, as does bottle.
http://www.techempower.com/benchmarks/#section=data-r9&hw=i7...