Think carefully before you build new projects on App Engine APIs. The idea that you will get more affordable scaling than other services without system administration is a complete fantasy. By the time you're deploying AppScale the fantasy is obvious because you are now doing all the normal work of scaling and normal system administration, and also the work of dealing with App Engine's flaws. But if you are green enough to get taken in by the fantasy once, then it probably won't be dispelled until after you've already lost months to years wishing you had chosen something else.
First you pay a heavy cost in extra development time to work around App Engine's idiosyncratic APIs, bizarre restrictions and quotas. Then you pay fees which are exorbitant by comparison with what you will get almost anywhere else. Then you may discover that support for the runtime you are using is lagging in a way that doubles your bills, and will never be fixed (and App Engine will never again have close to the interest and staffing it once had). How does it sound to rewrite in another language? Then you will discover and have to work around frequent service outages using the limited tools provided. All this with Google's famed lack of support - unless your spend is extremely high, which means you're losing even more money for having chosen App Engine. And let's just hope Google doesn't double, triple or quadruple monthly bills again.
If you run into any of these problems (and you will), you're stuck and your only real option is to move platforms, which means most of your code will have to be rewritten. AppScale is a final resort; there is no other option. If that doesn't work well for you, notably if the overhead of AppScale itself costs you too much, then you are still going to have to rewrite most of your code. If you don't already have a lot of App Engine code you can't replace, it isn't smart to plan to run a huge AppScale deployment.
If you think you will be doing a large deployment then you should look at technologies which were developed in the open from the beginning and which still have a lot of active momentum. Or just use normal Linux boxes and worry about scaling issues as you need to, like everyone else. Just don't get locked into weird vendor-specific APIs like App Engine.