Hi dangayle, the calculation is a little bit slow for now. It takes about 15 sec against 500x500 images in my environment, and here's an issue ticket for the speed improvement. https://github.com/fbessho/PyPoi/issues/12

I'm not sure how many sec is acceptable for you though. If you've done some analysis on it, it would be great if you can comment on the issue ticket (or even better if you can raise a pull request against it!).