Person-to-person e-mails, individually tailored and carefully laying out why you want to work for them and how you can provide value to their company, aren't generally seen as spam.

Where it gets into spam is if you send the same copy & pasted text to dozens of possible employers.

I wouldn't worry about that too much, if they ignore your email then it ends there. I don't think anyone will put your email on a worldwide blacklist because you sent a feeler email out.

I would be worried about sending my personal information that appears on my resume (phone numbers, address, full name) unwarranted to someone. I would start by sending a quick email explaining your skills and maybe a link to a portfolio or github, and ask about openings. If they express interest then I would further pursue. If they don't, all they know you by is your email address.