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Working with Excel spreadsheets in general is a mess. There really isn't a single library that does everything well and if you want of be able to get all the information like formatting, formulas, etc... the only really complete solution is to use pywin32 and com which requires Excel and isn't particularly fast or easy either.

It is a bit of a mess; documentation often amounting to a few example calls. However, I've written a fairly well received data analysis package for a government department wherein the input and output had to be in excel spreadsheets (-sigh-), using only xlrd and xlwt, alongside numpy and scipy. It's a bit Rubegoldbergian (because.. excel), but I owe a lot to the authors of xlrd and xlwt (they've even supported named regions). So i'll be curious to see how xlwings implements the numerous methods available from xlrd/xlwt.

xlsx: https://xlsxwriter.readthedocs.org/ powerpoint: http://python-pptx.readthedocs.org/en/latest/ word: https://pypi.python.org/pypi/docx/0.2.4