Artificial selection also appears to work in unusual ways. We don't really understand the mechanics of it. Foxes were selectively bred in several experiments (and for the fur trade) for tameness. Basically breeding only foxes that don't bite or recoil from people.

The breed developed a whole range of dog like characteristic, behavioral and morphological. They whine and bark (which neither wolves or wild foxes do). They develop a diversity of coloration. I've even heard some had cute floppy ears. Obviously there is a corollary to dog evolution, which we don't really understand either.

Selecting for a trait or a family of traits in humans will probably have unexpected side effects.