That being said, I see bio-engineering as much more likely and immediately possible route to human extinction. But I suppose we could also have artificial intelligence guiding bio-engineering which might speed the process up....
Most likely, the eventual extinction of the current human species is inevitable. It has happened plenty of times before. There were other hominid species before and during the time Homo Sapiens appeared, we still carry some of their genes but they are extinct. Why would we suppose our particular species will be any different? Life is succession of organisms. And it doesn't seem the function of life is to preserve species, but rather to preserve and enhance genes.
Oh I know... Being human, I'm not crazy about the idea either. But I can't help seeing our position within the larger framework. I can't believe we are at the pinnacle of what life can become, nor do I believe the process of evolution will forever freeze with the appearance of this strange kind of ape.
Maybe the next iteration of apes will spend more time doing things other than looking under trees for nuts to hide in their nests and sharpening sticks to poke other monkeys..... Because it seems these are some of the primary occupations of the variety to which I belong. Then again, maybe they will do exactly this, but much better. Probably. Ah well... life. If you can't beat it, join it. Now were did I leave my stick at?