Myself, no. It's been my experience that AV programs only warn after it's too late and you've already been owned by some nasty bit of code. Gee, thanks for nothing, time to flatten and reinstall. There's also the problem that literally every one I've found on a Windows platform appears to be designed for the lowest common denominator, easily frightened end user - scary warnings and dire predictions about what might happen if I don't renew my subscription (another problem, you have to subscribe to all of these on a recurring basis), Fisher-Price level UI, and so on.

To borrow a phrase from the /g/ community, I run Common Sense 2014 platinum edition. I.e. I don't download stuff from sketchy websites in general, I don't click email attachments, I don't use the Java web plugin, I do use things like Adblock and Noscript, etc.

If I do end up with a possibly suspicious file it gets sent off to a multi-scanner environment like VirusTotal or Jotti where I can get about 30 different opinions simultaneously.

The last few infections I've gotten were due to doing something boneheaded. Running something from a torrent without checking it first, or turning my browser security off temporarily and forgetting to reenable it.