I do not use them but they say "That’s why Backblaze backs up your data automatically and constantly looks for new and changed files to backup. Install Backblaze and never worry about losing a file again."
Unless you are running a database it seems like the most common use case for files is write once, update every once in a while. Document creation (code for us or office docs non-coders) would be a bunch of writes up front then follow the same pattern of update every once in a while
I suppose their reads are much less than a typical user, but I didnt think reads contributed much to eventual drive failure