Disco seems to be purely a MapReduce framework?
This, in turn, might be something you'd use to build a tailored distributed system where you'd call out to Python (and its ecosystem, like Pandas, etc.) to do your own data processing.
My personal interest in it is that it uses LISP Flavored Erlang (lfe.io) and might therefore be nice to use with Hy (hylang.org)
As for Hy: LFE py comes with custom ErlPort encoders/decoders, and I came this close to writing those in Hy. However, I did want anyone with a Python background to be able to easily read and contribute, not just Lispers ;-)
Regardless, it would be nice to use with Hy (and probably trivial: a requirements.txt update, and then adding some Hy modules in ./python/lfe, at which point you should be able to access them from LFE).
Disco was designed for data-intensive workloads. It wouldn't make much sense to use it to supervise Python servers/services, for instance.