We know that humans are not capable of converting 100% of food's available energy. What if your body is less capable of breaking down certain types of food right after you wake up? what if consuming a large portion of your daily diet in once overwhelms your body's ability to digest it. Science may have solved those specific questions, but pretending that the complex bag of chemical reactions in the human digestive tract is entirely governed by two simple summation variable seems naive. Please forgive any formatting errors. I'm typing this on a tiny little phone
The point I was making is that the equation isn't calories_in + calories_out = weight_loss/gain. It is at least x(calories_in) + y(calories_out) = weight_loss/gain where x and y are complex physical and chemical variables that we haven't completely teased out yet. One less than insignificant part of x seems to be related to the time window of consumption. A small change in x or y would result in significant improvements over the course of a life.