It's not the method, it's the toxicity of the chemical itself. As others have mentioned, regardless of the method of extraction, purification, or intake, this does not change the ridiculous amount that would have to be pumped into the blood in order to kill someone.
Cannabinoids do not affect the brain stem, the primitive part of the brain that controls respiration and the heart. Many other drug overdoses are affected through this avenue. Cannabis does not and cannot.
You would have to adulterate it with another drug, in which case, it is a different discussion.