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I do this with a trackball; I learned to wiggle the mouse with my left hand because it fits with my desk better, and, like the product above points out, it's a little more ergonomic to avoid flying over the numpad.

In my experience, trackballs have a tendency to better support ambidextrousness.

If you're left handed...

Your left hand, assuming you have one, is not a useless appendage. It doesn't take much training to teach it to use the mouse. And then you can easily take notes while you work. Switching mouse hands was one of my better moves, I think. I now bitterly rue the years I spent wasting my time pushing it around with my writing hand. I can't play mouse games left-handed, but that's a small price to pay; the mouse is easily moved when necessary.

Bonus points: you get to do a subtle social dominance power move if you sit at a left-hander's desk to help them out. (A statement that is made with tongue in cheek, but appears to be the truth nonetheless...)

best weird habit I've ever acquired. Took only 3 days.